百特支持一项显示COVID-19危重患者营养需求的新研究，并发布了实用护理指南

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DEERFIELD, Ill. - 2020-10-14

Baxter International Inc. (NYSE:BAX), a global leader in nutrition therapy, supports interim findings of an ongoing prospective study, "COVID-19重症患者持续高代谢与纵向能量消耗,“证明了间接量热法(IC)在提高COVID-19患者重症监护病房(ICU)住院期间营养需求测量准确性方面的作用. 该研究由百特通过研究者发起的拨款支持，最近发表在 Critical Care, 是对危重患者纵向静息能量消耗(REE)的首次分析吗, mechanically ventilated COVID-19 patients. The interim findings of 22 U.S. 患者评估超过21天提示预测方程, 哪些是通常用来评估病人营养需求的, are largely inaccurate for this patient population. 作者观察到患者在ICU住院期间的进行性高代谢和REE的显著变化, 这表明依赖预测方程可能会导致COVID-19患者饮食不足, particularly later in their ICU stay. 这一点值得注意，因为人们对COVID-19危重患者的营养需求知之甚少, 因为过去对ICU患者的研究表明，过度喂养和不足喂养与不良预后有关, including mortality¹.

"To deliver safe, individualized nutrition, 临床医生需要了解病人在住院期间的新陈代谢动态变化," said Jorge Vasseur, general manager, Baxter's Clinical Nutrition business. "While much remains unknown about COVID-19 patients, 足球外围最靠谱的网站感到鼓舞的是，这项史无前例的研究能够阐明这部小说的作用 Q-NRG+ 间接量热技术可以为这一人群提供个性化的营养护理."

During the study, 是由百特公司通过研究者发起的拨款资助的, 每三天用间接量热法(mREE)测量一次能量需求，并根据哈里斯-本尼迪克特方程(HBE)与预测的能量需求进行比较。. 在ICU第一周后观察到高代谢和更广泛的mREE变异性. 观察到的高代谢持续存在，在ICU第三周mREE增加，平均mREE为预测值的150%. In some cases, REE比HBE预测的高2倍, 在ICU第一周后显著低估了REE. 这项研究的发现与之前发表的文献一致^1,2 在病人住院期间测量病人的营养需求和定制营养疗法的重要性, as REE changes during this time.

“客观数据对于指导营养供应和防止有害的过度和不足喂养至关重要, 本研究表明，很难准确预测ICU患者的能量需求," noted the study's author, Paul E. Wischmeyer, M.杜克大学医学院的D, EDIC, FASPEN, FCCM. “就像临床医生不会在不测量病人血压的情况下给病人使用血管加压药一样, 足球外围最靠谱的网站需要以同样的客观标准来看待营养保健, 现在有了精确而简单的间接量热仪，这是可能的."

In partnership with COSMED SRL, Baxter introduced Q-NRG+, 利用间接量热(IC)技术的代谢监测装置, in the U.S. earlier this year. Q-NRG+ 2019年之前是否在其他几个市场有售. IC is considered the "gold standard"³ when assessing a patient's calorie needs, or REE. 这些读数可以帮助营养疗法的处方和管理, which may include parenteral nutrition (PN), the intravenous administration of nutrients.     

Guidelines for Indirect Calorimetry During COVID-19

COVID-19对医院如何在患者体验的许多方面提供护理提出了挑战, 这些挑战延伸到间接量热法的安全使用. The recent publication, "COVID - 19大流行期间间接量热法使用的实用指南,为保护医疗保健提供者及其所支持的COVID-19患者的安全提供了指导. In addition, the manufacturer of Q-NRG+, COSMED, 是否编译了解释该设备如何设计以将受污染部件造成的感染风险降至最低的信息, including use of disposable filters, 连同正确清洁和消毒可重复使用部件的说明. LEEP-COVID研究强调了间接量热法在该人群中安全进行的重要性, 这也是欧洲临床营养与代谢学会(ESPEN)为ICU患者支持的一种方法.

About Baxter's Clinical Nutrition Portfolio

除了提供许多必要的成分，以创建良好的平衡配方的临床营养方案, 百特提供创新和可访问的产品和服务，旨在用于不同的医疗保健环境, including in the ICU and the hospital, nursing homes, clinics and in homes.

About Baxter

Every day, 数以百万计的患者和护理人员依赖百特领先的重症监护产品组合, nutrition, renal, hospital and surgical products. For more than 85 years, 足球外围最靠谱的网站一直在关键的十字路口运作，在这里，拯救和维持生命的创新与实现它的医疗保健提供者相遇. With products, 100多个国家提供技术和疗法, 百特在全球的员工正在以公司丰富的医疗突破传统为基础，推进下一代变革性医疗创新. To learn more, visit www.ekrist.net and follow us on Twitter, LinkedIn and Facebook.

About COSMED

COSMED, established in 1980, 是一家设计和制造心肺和代谢诊断设备的私营公司吗. COSMED solutions address needs of the healthcare, academic and industry markets to assess human metabolism, exercise physiology, 用于临床和研究目的的肺功能和体成分. COSMED products include a full range of spirometers, indirect calorimetry, 心肺运动测试和身体成分系统，包括软件. COSMED headquarters are located in Rome, Italy with direct operations in Australia, France, Germany, Hong Kong, Netherlands, Switzerland, UK and United States, 商业伙伴网络覆盖80多个国家. Visit www.cosmed.com to know more about COSMED.

Indications for Use

The Q-NRG+ 便携式代谢监测器用于测量自发呼吸和通气患者的静息能量消耗(REE), within the following populations:

• 使用顶棚时体重超过15公斤(33磅)的自发呼吸受试者.
• 6岁以上、使用口罩时体重超过10公斤(22磅)的自发呼吸受试者.
• 10岁以上、体重超过10公斤(22磅)的通气对象.

Rx Only. The Q-NRG+便携式代谢监测器仅适用于专业医疗机构. For safe and proper use of the devices mentioned herein, refer to the complete instructions in the Operator's Manual.

This release includes forward-looking statements concerning Q-NRG+, including potential benefits associated with its use. 这些陈述是基于对许多重要因素的假设, including the following, which could cause actual results to differ materially from those in the forward-looking statements: satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; product quality, manufacturing or supply, or patient safety issues; changes in law and regulations; and other risks identified in Baxter's most recent filing on Form 10-K and other SEC filings, all of which are available on Baxter's website. 百特不承诺更新其前瞻性声明.

Baxter is a trademark of Baxter International Inc. Q-NRG+ is a trademark of COSMED.  

¹ Zusman et al. Resting energy expenditure, 危重病人的热量和蛋白质消耗:一项回顾性队列研究. Critical Care (2016) 20:367. DOI: 10.1186/s13054-016-1538-4.

² Zusman et al. 预测方程与间接量热法测量的能量消耗:回顾性验证. Clinical Nutrition (2019) Jun;38(3):1206-1210. DOI: 10.1016/j.clnu.2018.04.020. Epub 2018 May 8.

³ Frankenfield D, Ashcraft C. Estimating Energy Needs in Nutrition Support Patients. Journal of Parenteral and Enteral Nutrition. 35(5). 2011. 563-570.